Top 10 AI x DeFi : The year 2025 is becoming a defining chapter in the convergence of artificial intelligence (AI) and decentralized finance (DeFi). Together, they are forging what many now call AI x DeFi or DeFAI — a movement that blends algorithmic intelligence with the transparency and accessibility of blockchain. What began as isolated experiments is now turning into a full-fledged ecosystem, with projects creating intelligent agents, conversational tools, and self-executing strategies that reduce human effort while expanding financial opportunities.
This new wave of protocols is not just a technological trend but also a response to long-standing issues in crypto. Markets that once required constant monitoring are now increasingly automated. Financial services that were complex and intimidating are being translated into natural, human-like interfaces. Even strategies traditionally reserved for hedge funds are now accessible to everyday users. Against this backdrop, it’s worth exploring the top 10 AI x DeFi protocols in 2025, the projects that embody where intelligent finance is heading next.
Why AI x DeFi Matters in 2025 – Top 10 AI x DeFi
DeFi promised to remove intermediaries, but in practice it often left users juggling complicated tools, facing high risks, and managing portfolios with little guidance. AI addresses these gaps by introducing automation, personalization, and intelligence into the mix. Algorithms can scan liquidity pools, execute arbitrage, or liquidate risky positions faster and more accurately than humans. At the same time, machine learning models can learn user behavior and adapt strategies to suit their unique risk profiles.
Accessibility is also improving. Conversational assistants and intent-based platforms allow users to engage in finance without needing technical knowledge. A newcomer can type a simple request — “show me the best yield for stablecoins” — and an AI agent executes the command across multiple chains. For a sector that has often struggled with usability, this is a major leap.
Still, the rise of AI x DeFi raises important questions. Can these systems be trusted? What happens if an AI agent malfunctions or is exploited? And how will regulators react to financial services that are increasingly autonomous? These uncertainties exist alongside optimism, creating both excitement and caution in equal measure.
ChainGPT (CGPT) — Building the AI Infrastructure for Web3
Source: Cointelegraph
ChainGPT has become one of the most talked-about players in the AI x DeFi ecosystem because it offers more than a single product — it is an infrastructure stack designed to bring AI into every corner of Web3. Its features include an AI-powered smart contract generator, NFT utilities, and an intelligent chatbot that can interact with blockchain protocols. Perhaps the most ambitious component is the AI Virtual Machine (AIVM), which allows AI agents to operate directly on-chain. This represents a shift from AI as a support tool to AI as a core participant in decentralized systems.
The CGPT token underpins the ecosystem, granting access to services, staking opportunities, and participation in ChainGPT’s launchpad. With a large and growing community, ChainGPT is not just a developer tool but also a cultural hub where builders and investors gather around the idea of decentralized intelligence. Its strength lies in positioning itself as the backbone of AI x DeFi innovation.
Supra (SUPRA) — AutoFi Layer-1 Blockchain
Source: Gate learn
Supra takes a different path by embedding automation into the blockchain itself. Unlike projects that build automation layers on top of existing chains, Supra is a purpose-built AutoFi Layer-1. This means automation is enshrined at the protocol level. Its services include native oracles, MEV (miner extractable value) protection, and secure cross-chain messaging.
The upcoming Supra 2.0 upgrade adds automatic arbitrage and liquidation features as part of its core architecture. This turns the blockchain into a platform where financial efficiency is not optional but built-in. With strong backing from Coinbase Ventures, Animoca Brands, and other well-known investors, Supra combines credibility with technological ambition. Its token supports governance, staking, and participation in this automation-first economy.
Newton Protocol (NEWT) — Securing Trust in AI Agents
Source: Pintu
For AI x DeFi to succeed, users must trust autonomous agents to execute strategies safely. Newton Protocol addresses this by focusing on verifiable automation. It combines Trusted Execution Environments (TEEs) with zero-knowledge proofs (ZKPs) to ensure that AI agents act securely and without manipulation. In other words, users do not have to simply take an agent’s word for it — they can verify its actions mathematically.
This emphasis on trust has helped Newton attract rapid adoption. With over one million sign-ups and more than 280,000 agents already deployed, it is proving that users are ready to embrace AI agents when transparency is guaranteed. The NEWT token powers compute services, staking, and governance, making it a central part of the network’s growing ecosystem.
Solidus Ai Tech (AITECH) — Compute Power Meets DeFi
Source: GateLearn
Solidus Ai Tech brings a practical but vital piece to the puzzle: computing power. AI models require vast GPU resources, and Solidus operates a high-performance data center while offering a GPU marketplace where users can rent or provide compute resources. What makes this project stand out is how it ties these services into DeFi incentives.
Its Agent Forge is a no-code builder that allows anyone to create and deploy AI agents without technical expertise, broadening access to intelligent automation. Meanwhile, the AITECH Pad serves as a launchpad for new AI and Web3 projects. With deflationary tokenomics — including a burn mechanism — the AITECH token integrates compute economics with financial incentives, ensuring alignment between supply, demand, and ecosystem growth.
Hey Anon (ANON) — Making DeFi Conversational
Source: Inside bitcoin
One of the most intimidating parts of DeFi is its complexity, and Hey Anon addresses this head-on with a conversational AI assistant. Instead of navigating multiple dashboards and interfaces, users can issue plain-language commands like “Bridge my USDC to Arbitrum” or “Show me the highest yield on stablecoins.” Hey Anon then executes the request across chains and provides results in real time.
Beyond commands, Hey Anon aggregates information from social media, market data, and on-chain sources, creating a holistic assistant that informs as well as acts. Its partnership with DWF Labs gives it momentum, and its agents extend beyond convenience into real-time risk management and multi-step strategy execution. For users overwhelmed by DeFi’s complexity, Hey Anon feels like a much-needed simplification.
GRIFFAIN (GRIFFAIN) — Solana’s Intelligent DeFi Engine
Source: griffain
Built on Solana, GRIFFAIN is designed for speed and scalability. Its Agent Engine powers a wide range of activities: trading, NFT interactions, memecoin strategies, and even copy-trading. The project introduces the @ Store, a marketplace where users can deploy AI agents tailored for different purposes.
GRIFFAIN has experienced rapid growth, supported by its listing on Binance futures and growing adoption within the Solana ecosystem. Its token fuels transaction fees, staking, and governance. By combining Solana’s efficiency with AI-driven automation, GRIFFAIN is carving out a unique space in the AI x DeFi ecosystem.
Hive AI (BUZZ) — Intent-Based Multi-Agent Finance
Hive AI simplifies DeFi interaction through an intent-based approach. Users simply state what they want to achieve — “maximize stablecoin yield” or “diversify into AI tokens” — and the system’s Orchestrator Agent translates these goals into a series of automated strategies. Specialized agents then execute tasks across lending, trading, and analytics platforms.
As a Solana AI Hackathon winner, Hive AI has quickly gained credibility and adoption. The BUZZ token powers governance, fees, and incentives. Its strength lies in making DeFi intuitive while ensuring complex strategies remain accessible to everyday users.
Fetch.ai (FET) — Multi-Agent AI Economy
Fetch.ai is one of the most mature projects on this list. Its decentralized network of AI agents was originally designed for tasks like data exchange and real-world automation, but it has now expanded into DeFi. Agents can autonomously trade, manage liquidity, and share data, creating a multi-agent economy where financial automation happens at scale.
The FET token powers agent operations, transactions, and ecosystem services. With cross-industry partnerships that span beyond crypto, Fetch.ai represents a broader vision where AI and blockchain extend into logistics, energy, and finance simultaneously.
SingularityDAO (SDAO) — AI-Driven Hedge-Fund Strategies
Source: GateLearn
A spin-off from the SingularityNET ecosystem, SingularityDAO focuses on AI-powered asset management. Its DynaSets are actively managed baskets of crypto assets that use machine learning to rebalance portfolios and maximize returns while reducing risk. In effect, it democratizes hedge-fund-level strategies for retail investors.
The SDAO token governs the platform and incentivizes users to participate. By merging DeFi with AI-driven asset management, SingularityDAO is a bridge between traditional financial sophistication and blockchain accessibility.
Numerai (NMR) — Data Science Meets DeFi Predictions
Source: Changelly
Numerai has long been a pioneer in combining AI and finance. Its hedge fund is powered by a global network of data scientists who submit predictive models. With the Erasure protocol, Numerai decentralizes this process, creating markets where accurate models are rewarded, and poor ones penalized.
Now entering DeFi integrations, Numerai is applying its years of AI expertise to decentralized prediction markets and automated asset management. The NMR token incentivizes quality contributions while ensuring participants have skin in the game.
Comparative Table: Top 10 AI x DeFi Protocols 2025
| Protocol | Category | Main Use Case | Standout Feature |
|---|---|---|---|
| ChainGPT (CGPT) | Infrastructure | AI tools, smart contract generation | AI Virtual Machine (AIVM) |
| Supra (SUPRA) | AutoFi Layer-1 | Native automation and oracles | Auto-arbitrage and liquidation at protocol level |
| Newton (NEWT) | Trust Layer | Secure AI agents | TEEs + ZKPs for verifiable automation |
| Solidus (AITECH) | Compute + DeFi | GPU marketplace + AI agent builder | No-code Agent Forge |
| Hey Anon (ANON) | Conversational AI | Natural language DeFi assistant | Executes multi-chain tasks via plain commands |
| GRIFFAIN | Solana Ecosystem | Trading, NFTs, copy-trading agents | @ Store marketplace for agents |
| Hive AI (BUZZ) | Intent-Based System | Translating goals into automated strategies | Orchestrator Agent with specialized modules |
| Fetch.ai (FET) | Multi-Agent Economy | Autonomous trading and data exchange | Decentralized network of financial agents |
| SingularityDAO | Asset Management | AI-driven portfolio rebalancing | Hedge-fund grade DynaSets |
| Numerai (NMR) | Prediction Protocol | Crowdsourced AI financial models | Erasure protocol for decentralized predictions |
Risks and Challenges Ahead – Top 10 AI x DeFi
Even as these projects expand, significant risks remain. AI agents can malfunction, smart contracts can be exploited, and regulatory frameworks are unclear. The volatility of experimental tokens creates uncertainty for investors. Scalability is also a challenge — running thousands of AI agents simultaneously could strain blockchains if not managed properly.
Users must balance excitement with caution, recognizing that while the potential is transformative, the risks are real.
Looking Beyond 2025- Top 10 AI x DeFi
The future of AI x DeFi could be transformative. We may see AI-driven DAOs that govern protocols, personalized robo-advisors that guide retail users, and institutions using AI for compliance and risk management. Data marketplaces might merge with liquidity pools, creating entirely new types of financial instruments.
If adoption grows, the combination of AI and decentralized finance could expand into a trillion-dollar sector, changing not only crypto but finance itself.
Conclusion – Top 10 AI x DeFi
The top 10 AI x DeFi protocols in 2025 showcase the variety and ambition shaping this new sector. From infrastructure projects like ChainGPT and Supra to user-centric platforms like Hey Anon and Hive AI, each represents a step toward intelligent, decentralized finance.
As this field matures, the opportunities for automation, personalization, and transparency are immense. Yet users should remain mindful of the risks. What’s clear is that AI x DeFi is more than a passing experiment — it is the beginning of a new era where finance is not only decentralized but also intelligent.
